Humacyte, Inc. HUMA R2K
Humacyte, Inc., together with its subsidiaries, engages in the development and manufacture of off-the-shelf, implantable, and bioengineered human tissues for the treatment of diseases and conditions across a range of anatomic locations in multiple therapeutic areas. The company using its proprietary and scientific technology platform to engineer and manufacture human acellular vessels (HAVs) to be implanted into patient without inducing a foreign body response or leading to immune rejection. It is developing a portfolio of HAVs, which would target the vascular repair, reconstruction, and replacement market, including vascular trauma; arteriovenous access for hemodialysis; peripheral arterial disease; pediatric heart surgery; and coronary artery bypass grafting, as well as for the delivery of cellular therapy, including pancreatic islet cell transplantation to treat Type 1 diabetes. Humacyte, Inc. was founded in 2004 and is headquartered in Durham, North Carolina.
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Valuation
Profitability & Returns
Balance Sheet & Liquidity
Ownership
Financial Snapshot
Growth (CAGR)
PROS
No notable strengths flagged.
CONS
- Earnings shrank at -80.4% CAGR over 5 years.
- Trading 52.4% below its 52-week high.
- In a downtrend (50-DMA below 200-DMA).
* The pros and cons are auto-generated from financial metrics.
Price Chart
Technical Trend
Computed from daily close history using EMA cross, slope, and RSI signals.
Note: intraday data is not stored locally. “Hourly” uses the most recent 10 daily candles as a short-term proxy.
Fundamental Growth
No fundamental data available for this stock.
Figures from the latest reported periods. CAGR is computed across the displayed window (quarterly CAGR is annualised assuming 4 quarters per year).
Peer comparison
Peer companies in the same sector (Healthcare).
| # | Name | CMP $ | P/E | Mkt Cap | Div Yld % | ROCE % | ROE % | Rev CAGR 5Y % | Profit CAGR 5Y % |
|---|---|---|---|---|---|---|---|---|---|
| 1 | HUMA Humacyte, Inc. R2K | 1.30 | - | $288.62M | - | -30.19% | - | - | -80.42% |
| 2 | LLY Eli Lilly and Company SPX | 1,105.00 | 39.21 | $985.37B | 0.63% | 38.44% | 107.46% | 31.69% | 48.96% |
| 3 | JNJ Johnson & Johnson SPX | 225.33 | 26.11 | $542.42B | 2.38% | 23.13% | 26.42% | 5.60% | 14.32% |
| 4 | UNH UnitedHealth Group Incorporated SPX | 380.31 | 28.66 | $345.38B | 2.32% | 9.60% | 12.18% | 11.35% | -15.69% |
| 5 | MRK Merck & Co., Inc. SPX | 118.72 | 33.44 | $293.22B | 2.86% | 20.66% | 18.94% | 3.12% | 7.93% |
| 6 | TMO Thermo Fisher Scientific Inc. SPX | 492.51 | 27.11 | $183.03B | 0.38% | 9.17% | 13.52% | -0.27% | -1.19% |
| 7 | AMGN Amgen Inc. NDXSPX | 336.79 | 23.42 | $181.77B | 2.99% | 18.02% | 101.32% | 11.77% | 5.58% |
| 8 | GILD Gilead Sciences, Inc. NDXSPX | 134.43 | 18.29 | $166.90B | 2.44% | 22.92% | 43.36% | 2.57% | 22.83% |
| 9 | ISRG Intuitive Surgical, Inc. NDXSPXAI | 424.64 | 51.53 | $150.39B | - | 15.96% | 17.23% | 17.39% | 29.26% |
Quarterly Results
Figures in USD.
| Metric | Mar 2020 | Jun 2020 | Sep 2020 | Mar 2021 | Jun 2021 | Sep 2021 | Mar 2022 | Jun 2022 | Sep 2022 | Mar 2023 | Jun 2023 | Sep 2023 | Mar 2024 | Jun 2024 | Sep 2024 | Dec 2024 | Mar 2025 | Jun 2025 | Sep 2025 | Dec 2025 | Mar 2026 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | - | - | 517.00K | 301.00K | 753.00K | 467.00K | 495.00K |
| Cost of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 147.00K | 213.00K | 260.00K | 9.08M | 2.04M |
| Gross Profit | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 370.00K | 88.00K | 493.00K | -8.62M | -1.54M |
| Operating Expenses | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 23.55M | 29.82M | 24.88M | 22.22M | 27.39M |
| Operating Income | - | - | -17.21M | -19.77M | -19.27M | -20.54M | -21.76M | -18.53M | -23.49M | -22.51M | -26.73M | -24.62M | -26.58M | -29.50M | - | - | -23.18M | -29.73M | -24.39M | -30.84M | -28.93M |
| EBITDA | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 43.97M | -33.25M | -13.03M | -19.92M | -13.56M |
| Interest Expense | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 3.00M | 2.54M | 2.61M | 3.09M | 2.27M |
| Pretax Income | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 39.14M | -37.66M | -17.51M | -24.80M | -17.62M |
| Tax Provision | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Net Income | -17.67M | -14.88M | -17.76M | -20.30M | -17.20M | -31.56M | -19.83M | 36.87M | -25.28M | -36.97M | -22.71M | -26.00M | -31.90M | -56.66M | - | - | 39.14M | -37.66M | -17.51M | -24.80M | -17.62M |
| Diluted EPS | - | - | -3.07 | -3.46 | -2.89 | -0.72 | -0.19 | 0.35 | -0.25 | -0.36 | -0.22 | -0.25 | -0.29 | -0.48 | - | -0.16 | 0.28 | -0.24 | -0.11 | - | -0.09 |
| R&D Expense | - | - | 14.69M | 15.14M | 14.57M | 15.39M | 16.31M | 14.65M | 17.34M | 17.28M | 20.54M | 18.55M | 21.26M | 23.75M | 22.93M | - | 15.42M | 22.01M | 17.27M | - | 19.46M |
Profit & Loss (Annual)
Figures in USD.
| Metric | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|---|
| Revenue | - | - | 0 | 0 | 0 | 2.04M |
| Cost of Revenue | - | - | - | - | 0 | 9.70M |
| Gross Profit | - | - | - | - | 0 | -7.66M |
| Operating Expenses | - | - | 84.58M | 100.05M | 114.40M | 100.47M |
| Operating Income | -64.60M | - | -84.58M | -100.05M | -114.40M | -108.14M |
| EBITDA | - | - | 2.44M | -96.46M | -132.23M | -22.24M |
| Interest Expense | - | - | 6.20M | 6.60M | 9.28M | 11.25M |
| Pretax Income | - | - | -11.96M | -110.78M | -148.70M | -40.83M |
| Tax Provision | - | - | - | - | - | - |
| Net Income | -66.52M | - | -11.96M | -110.78M | -148.70M | -40.83M |
| Diluted EPS | -11.54 | - | -0.12 | -1.07 | -1.26 | -0.26 |
| R&D Expense | 54.08M | 61.34M | 63.26M | 76.55M | 88.60M | 69.30M |
Compounded Sales Growth
| 5 Years: | - |
| 1 Year: | -4.30% |
Compounded Profit Growth
| 5 Years: | -80.42% |
| 1 Year: | - |
Stock Price Performance
| 1 Year: | -51.31% |
| 6 Months: | -1.52% |
| 3 Months: | +16.59% |
| 1 Month: | +58.54% |
Balance Sheet (Annual)
Figures in USD.
| Metric | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|---|---|
| Total Assets | - | 106.69M | - | 204.30M | 128.22M | 137.87M | 116.37M |
| Current Assets | - | - | - | 154.21M | 83.28M | 47.86M | 67.80M |
| Cash & Equivalents | - | 39.93M | - | 149.77M | 80.45M | 44.94M | 50.50M |
| Inventory | - | - | - | - | - | 0 | 13.59M |
| Receivables | - | - | - | 31.00K | 0 | 0 | 441.00K |
| Total Liabilities | - | 36.02M | - | 87.37M | 114.68M | 190.54M | 113.26M |
| Current Liabilities | - | 11.23M | - | 19.58M | 18.44M | 19.95M | 18.37M |
| Long Term Debt | - | - | 27.36M | 20.34M | 38.60M | - | 35.44M |
| Total Debt | - | - | - | 50.07M | 18.85M | 16.54M | 64.85M |
| Total Equity | -288.79M | -350.32M | - | 116.93M | 13.55M | -52.67M | 3.11M |
| Shares Outstanding | - | - | - | 103.23M | 103.67M | 130.03M | 193.00M |
Cash Flows (Annual)
Figures in USD.
| Metric | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|---|
| Operating Cash Flow | -55.57M | - | -71.13M | -73.31M | -98.12M | -105.04M |
| Investing Cash Flow | -268.00K | - | 4.84M | -173.00K | -1.57M | -884.00K |
| Financing Cash Flow | 2.05M | - | -1.45M | 4.51M | 114.18M | 61.49M |
| Capital Expenditure | -318.00K | - | -1.05M | -2.28M | -1.57M | -884.00K |
| Free Cash Flow | -55.89M | - | -72.18M | -75.58M | -99.69M | -105.93M |
| Net Change in Cash | - | - | -67.73M | -68.97M | 14.49M | -44.44M |
Ratios (Annual)
Figures in %.
| Metric | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|---|
| Gross Margin % | - | - | - | - | - | -376.1% |
| Operating Margin % | - | - | - | - | - | -5,306.0% |
| Net Margin % | - | - | - | - | - | -2,003.6% |
| ROE % | 19.0% | - | -10.2% | -817.8% | 282.3% | -1,313.4% |
| ROCE % | -67.7% | - | -45.8% | -91.1% | -97.0% | -110.4% |
Shareholding Pattern
Top Institutional Holders
| # | Holder | % Held | Shares | Value |
|---|---|---|---|---|
| 1 | Blackrock Inc. | 5.55% | 12.32M | $16.01M |
| 2 | Vanguard Capital Management LLC | 3.22% | 7.16M | $9.31M |
| 3 | Antipodes Partners Ltd. | 2.58% | 5.72M | $7.44M |
| 4 | Great Point Partners LLC | 1.69% | 3.75M | $4.87M |
| 5 | Geode Capital Management, LLC | 1.65% | 3.66M | $4.76M |
| 6 | State Street Corporation | 1.37% | 3.04M | $3.96M |
| 7 | UBS Group AG | 1.25% | 2.78M | $3.62M |
| 8 | Woodline Partners LP | 0.90% | 2.00M | $2.60M |
| 9 | AQR Capital Management, LLC | 0.87% | 1.92M | $2.50M |
| 10 | Vanguard Portfolio Management LLC | 0.64% | 1.42M | $1.84M |
Analyst View
Analyst aggregate. Targets and ratings update periodically; not investment advice.
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