Amylyx Pharmaceuticals, Inc. AMLX R2K
Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. The company also develops AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol which is phase 2 clinical trial for the treatment of wolfram syndrome, as well as in phase 2b/3 clinical trial to treat progressive supranuclear palsy; AMX0114, which is in phase 1 clinical trial for the treatment of amyotrophic lateral sclerosis; and long-acting GLP-1 receptor antagonist to treat post-bariatric hypoglycemia and other rare diseases. Further, it develops AMX0318, a GLP-1 receptor antagonist for the treatment of post-bariatric hypoglycemia and other rare diseaees. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.
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Valuation
Profitability & Returns
Balance Sheet & Liquidity
Ownership
Financial Snapshot
Growth (CAGR)
PROS
- In a confirmed uptrend (50-DMA above 200-DMA).
CONS
- Revenue declined at -33.3% CAGR over 5 years.
* The pros and cons are auto-generated from financial metrics.
Price Chart
Technical Trend
Computed from daily close history using EMA cross, slope, and RSI signals.
Note: intraday data is not stored locally. “Hourly” uses the most recent 10 daily candles as a short-term proxy.
Fundamental Growth
No fundamental data available for this stock.
Figures from the latest reported periods. CAGR is computed across the displayed window (quarterly CAGR is annualised assuming 4 quarters per year).
Peer comparison
Peer companies in the same sector (Healthcare).
| # | Name | CMP $ | P/E | Mkt Cap | Div Yld % | ROCE % | ROE % | Rev CAGR 5Y % | Profit CAGR 5Y % |
|---|---|---|---|---|---|---|---|---|---|
| 1 | AMLX Amylyx Pharmaceuticals, Inc. R2K | 14.35 | - | $1.60B | - | -49.46% | -63.26% | -33.33% | 9.01% |
| 2 | LLY Eli Lilly and Company SPX | 1,105.00 | 39.21 | $985.37B | 0.63% | 38.44% | 107.46% | 31.69% | 48.96% |
| 3 | JNJ Johnson & Johnson SPX | 225.33 | 26.11 | $542.42B | 2.38% | 23.13% | 26.42% | 5.60% | 14.32% |
| 4 | UNH UnitedHealth Group Incorporated SPX | 380.31 | 28.66 | $345.38B | 2.32% | 9.60% | 12.18% | 11.35% | -15.69% |
| 5 | MRK Merck & Co., Inc. SPX | 118.72 | 33.44 | $293.22B | 2.86% | 20.66% | 18.94% | 3.12% | 7.93% |
| 6 | TMO Thermo Fisher Scientific Inc. SPX | 492.51 | 27.11 | $183.03B | 0.38% | 9.17% | 13.52% | -0.27% | -1.19% |
| 7 | AMGN Amgen Inc. NDXSPX | 336.79 | 23.42 | $181.77B | 2.99% | 18.02% | 101.32% | 11.77% | 5.58% |
| 8 | GILD Gilead Sciences, Inc. NDXSPX | 134.43 | 18.29 | $166.90B | 2.44% | 22.92% | 43.36% | 2.57% | 22.83% |
| 9 | ISRG Intuitive Surgical, Inc. NDXSPXAI | 424.64 | 51.53 | $150.39B | - | 15.96% | 17.23% | 17.39% | 29.26% |
Quarterly Results
Figures in USD.
| Metric | Mar 2021 | Jun 2021 | Sep 2021 | Mar 2022 | Jun 2022 | Sep 2022 | Mar 2023 | Jun 2023 | Sep 2023 | Mar 2024 | Jun 2024 | Sep 2024 | Dec 2024 | Mar 2025 | Jun 2025 | Sep 2025 | Dec 2025 | Mar 2026 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | - | - | - | - | - | 345.00K | 71.43M | 98.22M | 102.69M | 88.64M | -1.02M | - | - | 0 | 0 | 0 | 0 | 0 |
| Cost of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 0 | 0 |
| Gross Profit | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 0 | 0 |
| Operating Expenses | - | - | - | - | - | - | - | - | - | - | - | - | - | 37.80M | 42.86M | 36.03M | 36.60M | 43.78M |
| Operating Income | -12.87M | -18.59M | -22.92M | -47.81M | -54.25M | -54.68M | -2.05M | 20.20M | 18.72M | -122.13M | -76.29M | - | - | -37.80M | -42.86M | -36.03M | -36.60M | -43.78M |
| EBITDA | - | - | - | - | - | - | - | - | - | - | - | - | - | -37.65M | -42.72M | -35.91M | -36.50M | -43.68M |
| Interest Expense | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Pretax Income | - | - | - | - | - | - | - | - | - | - | - | - | - | -35.91M | -41.44M | -34.39M | -32.95M | -41.28M |
| Tax Provision | - | - | - | - | - | - | - | - | - | - | - | - | -635.00K | 0 | 0 | 0 | 46.00K | - |
| Net Income | -14.52M | -21.92M | -23.14M | -47.85M | -54.07M | -53.76M | 1.57M | 22.07M | 20.89M | -118.79M | -72.70M | - | - | -35.91M | -41.44M | -34.39M | -33.00M | -41.28M |
| Diluted EPS | - | -3.41 | -3.42 | -0.93 | -0.93 | -0.92 | 0.02 | 0.31 | 0.30 | -1.75 | -1.07 | - | - | -0.42 | -0.46 | -0.37 | -0.30 | -0.37 |
| R&D Expense | 6.86M | 10.93M | 12.85M | 21.46M | 24.26M | 24.91M | 24.19M | 29.04M | 30.04M | 36.61M | 23.35M | 21.24M | - | 22.12M | 27.22M | 19.86M | - | 27.61M |
Profit & Loss (Annual)
Figures in USD.
| Metric | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|
| Revenue | - | 22.23M | 380.79M | 87.37M | 0 |
| Cost of Revenue | - | 2.99M | 25.44M | 124.63M | 0 |
| Gross Profit | - | 19.24M | 355.35M | -37.26M | 0 |
| Operating Expenses | - | 220.58M | 316.54M | 218.41M | 153.29M |
| Operating Income | - | -201.34M | 38.80M | -255.68M | -153.29M |
| EBITDA | - | -200.85M | 39.89M | -254.77M | -152.77M |
| Interest Expense | 0 | - | - | - | - |
| Pretax Income | - | -197.60M | 54.30M | -302.14M | -144.69M |
| Tax Provision | - | 774.00K | 5.03M | -393.00K | 46.00K |
| Net Income | - | -198.38M | 49.27M | -301.74M | -144.74M |
| Diluted EPS | -1.59 | -3.39 | 0.70 | -4.43 | - |
| R&D Expense | 44.04M | 93.45M | 128.19M | 104.08M | 90.40M |
Compounded Sales Growth
| 5 Years: | -33.33% |
| 1 Year: | - |
Compounded Profit Growth
| 5 Years: | 9.01% |
| 1 Year: | - |
Stock Price Performance
| 1 Year: | +178.64% |
| 6 Months: | -3.56% |
| 3 Months: | -5.41% |
| 1 Month: | -8.01% |
Balance Sheet (Annual)
Figures in USD.
| Metric | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|---|
| Total Assets | - | - | 391.45M | 517.45M | 193.63M | 332.64M |
| Current Assets | - | - | 382.13M | 464.67M | 189.43M | 323.67M |
| Cash & Equivalents | - | - | 62.53M | 170.20M | 77.39M | 226.65M |
| Inventory | - | 0 | 9.77M | 38.32M | 0 | - |
| Receivables | - | - | 15.31M | 40.05M | 447.00K | 88.00K |
| Total Liabilities | - | - | 50.85M | 84.02M | 28.87M | 27.39M |
| Current Liabilities | - | - | 46.61M | 82.04M | 28.41M | 22.69M |
| Long Term Debt | - | - | - | - | - | - |
| Total Debt | - | - | 6.28M | 4.24M | 1.98M | 5.96M |
| Total Equity | -66.72M | - | 340.61M | 433.43M | 164.76M | 305.26M |
| Shares Outstanding | - | - | 66.51M | 67.71M | 68.63M | 109.88M |
Cash Flows (Annual)
Figures in USD.
| Metric | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|
| Operating Cash Flow | - | -179.87M | 11.92M | -167.65M | -123.34M |
| Investing Cash Flow | - | -238.99M | 92.05M | 75.65M | 14.04M |
| Financing Cash Flow | - | 431.79M | 3.54M | 348.00K | 257.03M |
| Capital Expenditure | - | -2.53M | -1.24M | -157.00K | -138.00K |
| Free Cash Flow | - | -182.40M | 10.68M | -167.80M | -123.48M |
| Net Change in Cash | - | 12.93M | 107.52M | -91.64M | 147.72M |
Ratios (Annual)
Figures in %.
| Metric | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 |
|---|---|---|---|---|---|
| Gross Margin % | - | 86.5% | 93.3% | -42.6% | - |
| Operating Margin % | - | -905.7% | 10.2% | -292.6% | - |
| Net Margin % | - | -892.4% | 12.9% | -345.4% | - |
| ROE % | - | -58.2% | 11.4% | -183.1% | -47.4% |
| ROCE % | - | -58.4% | 8.9% | -154.7% | -49.5% |
Shareholding Pattern
Top Institutional Holders
| # | Holder | % Held | Shares | Value |
|---|---|---|---|---|
| 1 | FMR, LLC | 14.96% | 16.63M | $238.65M |
| 2 | Blackrock Inc. | 7.94% | 8.83M | $126.69M |
| 3 | Perceptive Advisors Llc | 7.45% | 8.28M | $118.89M |
| 4 | TCG Crossover Management, LLC | 5.62% | 6.24M | $89.60M |
| 5 | Commodore Capital Lp | 5.08% | 5.65M | $81.08M |
| 6 | Janus Henderson Group PLC | 4.48% | 4.99M | $71.55M |
| 7 | Saturn V Capital Management LP | 3.91% | 4.35M | $62.42M |
| 8 | Vanguard Capital Management LLC | 3.72% | 4.14M | $59.43M |
| 9 | Adage Capital Partners GP L.L.C. | 3.20% | 3.56M | $51.10M |
| 10 | First Light Asset Management, LLC | 2.87% | 3.19M | $45.79M |
Analyst View
Analyst aggregate. Targets and ratings update periodically; not investment advice.
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