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$54.19
+24.72% 1Y
Mkt Cap$8.85B
P/E-22.77
P/B18.09
52W High$86.50
52W Low$40.69
Book Value$2.99
EPS (TTM)$-2.38

Company Overview

IONS (IONS) is a publicly traded company listed on with a market capitalization of $8.85B. The valuation, growth and price-trend signals below summarize what matters most to investors and traders evaluating the stock.

Why Investors Should Care

Steady Revenue Expansion

Revenue has grown at a 13.7% CAGR over the past five years.

Recent Developments

  • Dec 2025 Revenue of $943.71M (+33.8% YoY); net profit $-381.39M.
  • Trailing 12 Months Year-on-year growth — revenue +33.8%.
  • 5-Year Trend Long-term compounding — revenue CAGR 13.7%.

Growth & Price Performance

Compounded Sales Growth

5 Years:13.65%
1 Year:33.83%

Stock Price Performance

1 Year:+24.72%
6 Months:-35.94%
3 Months:-27.99%
1 Month:-37.23%

Highlights auto-generated from reported financials and price data; not investment advice. Verify with official filings before acting.

Technical Snapshot Bearish
52-Week Range 29% of range
$40.69 $86.50
Trend Signals
  • Price vs 50-DMABelow
  • Price vs 200-DMABelow
  • RSI (14)35.13 · Neutral
Price Performance
1M-37.23%
3M-27.99%
6M-35.94%
1Y+24.72%

Auto-generated from price history and fundamentals; not investment advice.

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Price Chart

Robinhood TradingView

Fundamental Growth Charts

Interactive charts for Revenue, Net Income, EBITDA, Free Cash Flow, EPS, ROE, ROCE, Gross/Net/Operating Margin and more — switch metric and period using the dropdowns above. CAGR is computed across the displayed window (quarterly CAGR is annualised). Visual growth charts make it easy to spot multi-year compounding trends at a glance — far faster than reading raw numbers in a table.

PROS

  • Compounding revenue at 13.7% over 5 years.

CONS

  • Trading 37.4% below its 52-week high.
  • In a downtrend (50-DMA below 200-DMA).

* The pros and cons are auto-generated from financial metrics.

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Valuation

Stock P/E
-22.77
Industry PE
-
Forward P/E
-
PEG Ratio
-
Book Value
$2.99
Price to Book
18.09
P/S
-
EV/EBITDA
-
Dividend Yield
0.00%

Growth (CAGR)

Revenue 5Y
13.65%
Profit 5Y
-
Revenue (YoY)
33.83%
Earnings (YoY)
-

Profitability & Returns

ROCE
-13.92%
ROE
-77.98%
ROA
-10.82%
Profit Margin
-40.41%
Op Margin
-40.45%
Gross Margin
-
EPS (Latest Qtr)
$-0.69
EPS (TTM)
$-2.38

Balance Sheet & Liquidity

Debt/Equity
4.22
Quick Ratio
3.81
Current Ratio
3.83
Debt
$2.06B
Total Assets
$2.99B
Current Assets
$2.49B
Working Capital
$2.21B

Ownership

Promoter Holding
0.61%
Chg in Prom Hold
-
FII / Inst Holding
106.94%
Chg in FII Hold
-

Financial Snapshot

Enterprise Value
-
Total Revenue (TTM)
$943.71M
EBITDA
-
Free Cash Flow
$-320.03M
Operating Cash Flow
$-268.58M
Shares Outstanding
163.30M
Gross Margin
-
Payout Ratio
-
Financial Statements Quarterly Results · Profit & Loss · Balance Sheet · Cash Flows · Ratios

Quarterly Results

Figures in USD.

Metric Sep 2016Dec 2016Mar 2017Jun 2017Sep 2017Dec 2017Mar 2018Jun 2018Sep 2018Dec 2018Mar 2019Jun 2019Sep 2019Dec 2019Mar 2020Jun 2020Sep 2020Dec 2020Mar 2021Jun 2021Sep 2021Dec 2021Mar 2022Jun 2022Sep 2022Dec 2022Mar 2023Jun 2023Sep 2023Dec 2023Mar 2024Jun 2024Sep 2024Dec 2024Mar 2025Jun 2025Sep 2025Dec 2025Mar 2026Jun 2026
Revenue --115.80M112.27M118.31M-144.42M117.75M145.40M-297.21M163.81M167.89M-133.37M145.54M160.08M-111.61M125.75M133.09M-141.92M133.79M159.77M-130.52M188.41M144.21M-119.50M225.25M133.81M-131.61M452.05M156.72M-246.09M267.95M
Operating Income 16.11M41.16M19.48M6.45M11.31M-6.20M-3.30M-50.28M-18.57M10.78M121.53M-18.83M2.52M260.65M-61.13M-51.75M-36.54M-22.66M-91.97M-72.97M-85.85M220.60M-57.50M-85.51M-59.15M-208.02M-114.15M-90.19M-143.26M-6.12M-149.51M-66.09M-148.66M-110.82M-146.86M139.82M-160.18M-214.46M-117.42M-102.29M
Net Income 7.35M25.86M8.96M-3.08M-2.61M-2.92M-1.42M-40.36M-4.56M320.08M84.44M-876.00K26.16M184.41M-39.63M-25.64M-24.47M-354.53M-89.87M-80.88M-82.47M224.61M-65.17M-105.14M-46.99M-52.43M-124.32M-85.29M-147.41M-9.26M-142.80M-66.27M-140.48M-104.35M-146.94M123.55M-128.61M-229.39M-92.53M-114.65M
Diluted EPS 0.060.210.07-0.02-0.02-0.03-0.01-0.29-0.032.210.62-0.010.181.28-0.28-0.18-0.18-2.54-0.64-0.57-0.581.41-0.46-0.74-0.33-0.37-0.87-0.60-1.03-0.06-0.98-0.45-0.95-0.66-0.930.70-0.80-1.41-0.56-0.69

Profit & Loss (Annual)

Figures in USD.

Metric Dec 2008Dec 2009Dec 2010Dec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
Revenue 107.19M121.60M108.47M99.09M102.05M147.28M214.16M283.70M372.78M514.18M599.67M1.12B729.26M810.46M587.37M787.65M705.14M943.71M
Operating Income -13.06M-27.54M-48.36M-71.10M-68.92M-51.67M-47.73M-75.76M-20.16M31.05M-61.37M365.88M-172.08M-30.19M-410.19M-353.73M-475.08M-381.68M
Net Income -18.17M155.07M-61.25M-84.80M-65.48M-60.64M-38.98M-88.28M-60.40M346.00K273.74M278.14M-444.26M-28.60M-269.72M-366.29M-453.90M-381.39M
Diluted EPS -0.191.58-0.62-0.85----0.74-0.500.152.071.90-3.18-0.20-1.90-2.56-3.04-2.38
R&D Expense 106.44M134.62M145.16M153.10M154.60M173.70M238.90M319.50M340.40M372.50M411.90M461.50M531.00M638.20M-899.62M901.53M915.62M

Balance Sheet (Annual)

Figures in USD.

Metric Dec 2007Dec 2008Dec 2009Dec 2010Dec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
Total Assets --657.18M550.48M484.89M545.69M847.16M955.81M947.90M912.47M1.32B2.67B3.23B2.39B-2.53B2.99B3.00B3.52B
Current Assets ---------------2.20B2.64B2.62B2.99B
Cash & Equivalents 138.61M223.99M105.25M70.05M65.48M124.48M159.97M143.00M128.80M84.69M129.63M278.82M683.29M397.66M-276.47M399.27M242.08M372.26M
Inventory ---------------22.03M7.44M12.51M10.05M
Receivables ---------------25.54M97.78M92.19M66.06M
Total Liabilities --355.12M305.94M313.46M362.92M468.77M698.03M747.11M812.90M957.49M1.48B1.55B1.65B-1.96B2.60B2.42B3.03B
Current Liabilities --111.44M105.89M76.11M74.32M97.81M115.33M148.88M133.78M243.61M280.29M273.00M598.90M-311.56M448.09M309.32M781.57M
Long Term Debt ---------------1.18B1.23B1.25B1.35B
Total Debt ---------------1.37B1.45B1.42B2.06B
Total Equity 59.59M147.38M291.72M244.54M171.43M182.77M378.39M257.78M200.79M99.56M281.01M1.05B1.47B743.28M-572.89M386.69M588.35M489.09M
Shares Outstanding ---------------142.06M144.34M157.91M163.30M

Cash Flows (Annual)

Figures in USD.

Metric Dec 2008Dec 2009Dec 2010Dec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
Operating Cash Flow 212.03M-108.44M-63.59M-114.80M---21.12M-112.11M174.15M602.91M345.63M35.89M30.80M-274.37M-307.51M-500.95M-268.58M
Investing Cash Flow -234.25M-212.29M23.69M110.90M----60.05M56.60M-358.29M-929.56M-41.27M274.48M194.91M-262.64M-214.13M-134.03M-277.78M
Financing Cash Flow 107.58M202.00M4.70M-672.00K---24.73M11.39M229.09M475.87M100.02M-596.61M245.93M-55.30M644.08M478.06M675.84M
Capital Expenditure -13.66M-13.41M-13.24M-10.20M-1.48M-1.55M-7.52M-7.69M-7.11M-34.76M-13.61M-30.91M-35.12M-11.96M-15.72M-23.80M-45.28M-51.44M
Free Cash Flow 198.37M-121.86M-76.83M-125.00M---13.43M-119.21M139.38M589.30M314.72M772.00K18.84M-290.09M-331.32M-546.23M-320.03M
Share Buybacks ---------0034.40M90.55M00---

Ratios (Annual)

Figures in %.

Metric Dec 2008Dec 2009Dec 2010Dec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
Gross Margin % ------------------
Operating Margin % -12.2%-22.6%-44.6%-71.8%-67.5%-35.1%-22.3%-26.7%-5.4%6.0%-10.2%32.6%-23.6%-3.7%-69.8%-44.9%-67.4%-40.4%
Net Margin % -17.0%127.5%-56.5%-85.6%-64.2%-41.2%-18.2%-31.1%-16.2%0.1%45.6%24.8%-60.9%-3.5%-45.9%-46.5%-64.4%-40.4%
ROE % -12.3%53.2%-25.0%-49.5%-35.8%-16.0%-15.1%-44.0%-60.7%0.1%26.1%18.9%-59.8%--47.1%-94.7%-77.1%-78.0%
ROCE % --5.0%-10.9%-17.4%-14.6%-6.9%-5.7%-9.5%-2.6%2.9%-2.6%12.4%-9.6%--18.5%-13.9%-17.6%-13.9%

Shareholding Pattern

Insiders
0.61%
Institutions
106.94%
Public Float
107.60%

Analyst View

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Latest News

Recent headlines for IONS

Google News hu, 09 Jul 2026

IONS Stock Heads Toward Biggest Single-Day Slump In Over 5 Years – Retail Calls It ‘Opportunity Of A Lifetime’ - Yahoo Finance

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Google News Mon, 03 Aug 2026

Ionis Pharmaceuticals, Inc. (IONS) Stock Analysis: Exploring a 72% Potential Upside Amidst Challenging Metrics - DirectorsTalk Interviews

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Google News hu, 23 Jul 2026

Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% - HBSS - PR Newswire

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Google News hu, 30 Jul 2026

Ionis Pharmaceuticals (IONS) Stock Slips As Revenue Drops And Losses Return - simplywall.st

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Google News Fri, 31 Jul 2026

Insider Purchase: Director at $IONS Buys 5,000 Shares - Quiver Quantitative

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IONS — Frequently Asked Questions

What is the current share price of IONS?

As of 2026-08-05 17:25 PDT, IONS trades at $54.19 on NASDAQ/NYSE. Its 52-week range is $40.69 to $86.50.

What is the market capitalisation of IONS?

IONS has a market capitalisation of $8.85B on NASDAQ/NYSE.

What is the P/E ratio of IONS?

IONS trades at a trailing price-to-earnings (P/E) ratio of -22.77. Its price-to-book (P/B) ratio is 18.09.

What is the return on equity (ROE) of IONS?

IONS has a return on equity (ROE) of -77.98%. Its return on capital employed (ROCE) is -13.92%.

Is IONS a good stock to buy?

This page provides a data-driven analysis of IONS, including valuation ratios, profitability, growth trends, auto-generated pros and cons, peer comparison and AI exposure. Review these fundamentals alongside your own research and risk tolerance. This is informational content, not investment advice.

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